Identification of Endothelial Cell Protein C Receptor by Urinary Proteomics as Novel Prognostic Marker in Non-Recovery Kidney Injury.
Int J Mol Sci
; 25(5)2024 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-38474029
ABSTRACT
Acute kidney injury is a common and complex complication that has high morality and the risk for chronic kidney disease among survivors. The accuracy of current AKI biomarkers can be affected by water retention and diuretics. Therefore, we aimed to identify a urinary non-recovery marker of acute kidney injury in patients with acute decompensated heart failure. We used the isobaric tag for relative and absolute quantification technology to find a relevant marker protein that could divide patients into control, acute kidney injury with recovery, and acute kidney injury without recovery groups. An enzyme-linked immunosorbent assay of the endothelial cell protein C receptor (EPCR) was used to verify the results. We found that the EPCR was a usable marker for non-recovery renal failure in our setting with the area under the receiver operating characteristics 0.776 ± 0.065; 95%CI 0.648-0.905, (p < 0.001). Further validation is needed to explore this possibility in different situations.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Fatores de Coagulação Sanguínea
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Receptores de Superfície Celular
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Injúria Renal Aguda
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Insuficiência Cardíaca
Limite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Taiwan