Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy.
Int J Mol Sci
; 25(5)2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38474096
ABSTRACT
Aflatoxins are harmful natural contaminants found in foods and are known to be hepatotoxic. However, recent studies have linked chronic consumption of aflatoxins to nephrotoxicity in both animals and humans. Here, we conducted a systematic review of active compounds, crude extracts, herbal formulations, and probiotics against aflatoxin-induced renal dysfunction, highlighting their mechanisms of action in both in vitro and in vivo studies. The natural products and dietary supplements discussed in this study alleviated aflatoxin-induced renal oxidative stress, inflammation, tissue damage, and markers of renal function, mostly in animal models. Therefore, the information provided in this review may improve the management of kidney disease associated with aflatoxin exposure and potentially aid in animal feed supplementation. However, future research is warranted to translate the outcomes of this study into clinical use in kidney patients.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Suplementos Nutricionais
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Aflatoxinas
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Nefropatias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão