Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics.
NPJ Syst Biol Appl
; 10(1): 31, 2024 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-38499572
ABSTRACT
Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality. A primary challenge in developing these "living drugs" is the complexity of their pharmacology, as the drug product proliferates, differentiates, traffics between tissues, and evolves through interactions with patient immune systems. Using publicly available clinical data from Chimeric Antigen Receptor (CAR) T cells, we demonstrate how mathematical models can be used to quantify the relationships between product characteristics, patient physiology, pharmacokinetics and clinical outcomes. As scientists work to develop next-generation cell therapy products, mathematical models will be integral for contextualizing data and facilitating the translation of product designs to clinical strategy.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
Limite:
Humans
Idioma:
En
Revista:
NPJ Syst Biol Appl
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá