Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment.
Science
; 205(4413): 1405-7, 1979 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-38504
ABSTRACT
In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with drugs.
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Bases de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Encéfalo
/
Dopamina
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1979
Tipo de documento:
Article