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Added Value of Frequency of Imaging Markers for Prediction of Outcome After Intracerebral Hemorrhage: A Secondary Analysis of Existing Data.
Kuang, Lianghong; Fei, Shinuan; Zhou, Hang; Huang, Le; Guo, Cailian; Cheng, Jun; Guo, Wenmin; Ye, Yu; Wang, Rujia; Xiong, Hui; Zhang, Ji; Tang, Dongfang; Zou, Liwei; Qiu, Xiaoming; Yu, Yongqiang; Song, Lei.
Afiliação
  • Kuang L; Department of Neurology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.
  • Fei S; Department of Pediatrics, Huangshi Maternity and Children's Health Hospital, Affiliated Maternity and Children's Health Hospital of Hubei Polytechnic University, Huangshi, China.
  • Zhou H; Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Huang L; Postgraduate Joint Training Base of Huangshi Central Hospital, Wuhan University of Science and Technology, Huangshi, China.
  • Guo C; Postgraduate Joint Training Base of Huangshi Central Hospital, Wuhan University of Science and Technology, Huangshi, China.
  • Cheng J; Computer School, Hubei Polytechnic University, Huangshi, China.
  • Guo W; Department of Radiology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
  • Ye Y; Department of Radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, No. 141, Tianjin Road, Huangshigang District, Huangshi, 435000, China.
  • Wang R; Department of Radiology, Tangshan Gongren Hospital, Tangshan, China.
  • Xiong H; Department of Radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, No. 141, Tianjin Road, Huangshigang District, Huangshi, 435000, China.
  • Zhang J; Department of Clinical Laboratory, Xiangyang Central Haspital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Tang D; Department of Neurosurgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Zou L; Department of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Qiu X; Department of Radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, No. 141, Tianjin Road, Huangshigang District, Huangshi, 435000, China.
  • Yu Y; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Song L; Department of Radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, No. 141, Tianjin Road, Huangshigang District, Huangshi, 435000, China. song580lei@163.com.
Neurocrit Care ; 41(2): 541-549, 2024 Oct.
Article em En | MEDLINE | ID: mdl-38506972
ABSTRACT

BACKGROUND:

Frequency of imaging markers (FIM) has been identified as an independent predictor of hematoma expansion in patients with intracerebral hemorrhage (ICH), but its impact on clinical outcome of ICH is yet to be determined. The aim of the present study was to investigate this association.

METHODS:

This study was a secondary analysis of our prior research. The data for this study were derived from six retrospective cohorts of ICH from January 2018 to August 2022. All consecutive study participants were examined within 6 h of stroke onset on neuroimaging. FIM was defined as the ratio of the number of imaging markers on noncontrast head tomography (i.e., hypodensities, blend sign, and island sign) to onset-to-neuroimaging time. The primary poor outcome was defined as a modified Rankin Scale score of 3-6 at 3 months.

RESULTS:

A total of 1253 patients with ICH were included for final analysis. Among those with available follow-up results, 713 (56.90%) exhibited a poor neurologic outcome at 3 months. In a univariate analysis, FIM was associated with poor prognosis (odds ratio 4.36; 95% confidence interval 3.31-5.74; p < 0.001). After adjustment for age, Glasgow Coma Scale score, systolic blood pressure, hematoma volume, and intraventricular hemorrhage, FIM was still an independent predictor of worse prognosis (odds ratio 3.26; 95% confidence interval 2.37-4.48; p < 0.001). Based on receiver operating characteristic curve analysis, a cutoff value of 0.28 for FIM was associated with 0.69 sensitivity, 0.66 specificity, 0.73 positive predictive value, 0.62 negative predictive value, and 0.71 area under the curve for the diagnosis of poor outcome.

CONCLUSIONS:

The metric of FIM is associated with 3-month poor outcome after ICH. The novel indicator that helps identify patients who are likely within the 6-h time window at risk for worse outcome would be a valuable addition to the clinical management of ICH.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Neuroimagem Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurocrit Care Assunto da revista: NEUROLOGIA / TERAPIA INTENSIVA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Neuroimagem Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurocrit Care Assunto da revista: NEUROLOGIA / TERAPIA INTENSIVA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China