Direct comparison of the diagnostic performance of growth differentiation factor 8 in pediatric versus adult heart failure.
Clin Chim Acta
; 557: 117883, 2024 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-38521162
ABSTRACT
INTRODUCTION:
Growth differentiation factor 8 (GDF-8, myostatin) has been proposed for the management of adult heart failure (HF). Its potential role in pediatric HF patients is unknown. We sought to investigate its diagnostic performance in adult versus pediatric HF.METHODS:
GDF-8 was measured prospectively in pediatric and adult HF patients and in matching controls. HF was defined as the combination of typical symptoms and impaired left ventricular systolic function. Diagnostic performance for the detection of HF was evaluated by receiver operating characteristic (ROC) analysis.RESULTS:
We enrolled 137 patients with HF (85 pediatric) and 67 healthy controls (47 pediatric). Neither pediatric nor adult HF patients had significantly different GDF-8 levels compared to the reference groups (3.53 vs 3.46 ng/mL, p = 0.334, and 6.87 vs 8.15 ng/mL, p = 0.063, respectively), but pediatric HF patients had significantly lower GDF-8 levels compared to adult patients (p < 0.001). ROC analysis showed no significant improvement adding GDF-8 to NT-proBNP, age and sex (area under the curve (AUC) 0.870 vs 0.868, p = 0.614) in children and neither in addition to age nor sex in adult HF patients (AUC 0.74 vs 0.62, p = 0.110).CONCLUSION:
GDF-8 did not accurately differentiate between HF patients and normal comparators in neither adults nor in children.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Miostatina
/
Insuficiência Cardíaca
Limite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Áustria