Association of lipoprotein lipase (LPL) gene variants with hyperlipidemic acute pancreatitis in southeastern Chinese population.
Arch Endocrinol Metab
; 68: e230195, 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38530959
ABSTRACT
Objective:
The study aims to explore the relationship between lipoprotein lipase (LPL) variants and hyperlipidemic acute pancreatitis (HLAP) in the southeastern Chinese population. Subjects andmethods:
In total, 80 participants were involved in this study (54 patients with HLAP and 26 controls). All coding regions and intron-exon boundaries of the LPL gene were sequenced. The correlations between variants and phenotypes were also analysed.Results:
The rate of rare LPL variants in the HLAP group is 14.81% (8 of 54), higher than in controls. Among the detected four variants (rs3735959, rs371282890, rs761886494 and rs761265900), the most common variant was rs371282890. Further analysis demonstrated that subjects with rs371282890 "GC" genotype had a 2.843-fold higher risk for HLAP (odds ratio [OR] 2.843, 95% confidence interval [CI] 1.119-7.225, p = 0.028) than subjects with the "CC" genotype. After adjusting for sex, the association remained significant (adjusted OR 3.083, 95% CI 1.208-7.869, p = 0.018). Subjects with rs371282890 "GC" genotype also exhibited significantly elevated total cholesterol, triglyceride and non-high-density lipoprotein cholesterol levels in all the participants and the HLAP group (p < 0.05).Conclusion:
Detecting rare variants in LPL might be valuable for identifying higher-risk patients with HLAP and guiding future individualised therapeutic strategies.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Pancreatite
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Arch Endocrinol Metab
Ano de publicação:
2024
Tipo de documento:
Article