Global distribution, cross-species transmission, and receptor binding of canine parvovirus-2: Risks and implications for humans.
Sci Total Environ
; 930: 172307, 2024 Jun 20.
Article
em En
| MEDLINE
| ID: mdl-38599392
ABSTRACT
For canine parvovirus -2 (CPV-2), a zoonotic virus capable of cross-species transmission in animals, the amino acid changes of capsid protein VP2 are key factors when binding to other species' transferrin receptors (TfR). CPV-2 variants can spread from felines and canines, for example, to Carnivora, Artiodactyla, and Pholidota species, and CPV-2c variants are essential to spread from Carnivora to Artiodactyla and Pholidota species in particular. In our study, a CPV-2a variant maintained a relatively stable trend, and the proportion of CPV-2c gradually rose from 1980 to 2021. The VP2 amino acid sequence analysis showed that five amino acid mutations at 426E/D, 305H/D, and 297S may be necessary for the virus to bind to different host receptors. Meanwhile, receptor-binding loop regions and amino acid sites 87â¯L, 93â¯N, 232I, and 305Y were associated with CPV-2 cross-species transmission. The homology of TfRs in different hosts infected with CPV-2 ranged from 77.2â¯% to 99.0â¯%, and from pig to feline, canine, and humans was 80.7â¯%, 80.4â¯%, and 77.2â¯%, respectively. The amino acid residues of TfRs involved in the viral binding in those hosts are highly conserved, which suggests that CPV-2 may be capable of pig-to-human transmission. Our analysis of the origin, evolutionary trend, cross-species transmission dynamics, and genetic characteristics of CPV-2 when binding to host receptors provides a theoretical basis for further research on CPV-2's mechanism of cross-species transmission and for establishing an early warning and monitoring mechanism for the possible threat of CPV-2 to animal-human public security.
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Bases de dados:
MEDLINE
Assunto principal:
Parvovirus Canino
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Sci Total Environ
Ano de publicação:
2024
Tipo de documento:
Article