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Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection.
Giron, Leila B; Liu, Qin; Adeniji, Opeyemi S; Yin, Xiangfan; Kannan, Toshitha; Ding, Jianyi; Lu, David Y; Langan, Susan; Zhang, Jinbing; Azevedo, Joao L L C; Li, Shuk Hang; Shalygin, Sergei; Azadi, Parastoo; Hanna, David B; Ofotokun, Igho; Lazar, Jason; Fischl, Margaret A; Haberlen, Sabina; Macatangay, Bernard; Adimora, Adaora A; Jamieson, Beth D; Rinaldo, Charles; Merenstein, Daniel; Roan, Nadia R; Kutsch, Olaf; Gange, Stephen; Wolinsky, Steven M; Witt, Mallory D; Post, Wendy S; Kossenkov, Andrew; Landay, Alan L; Frank, Ian; Tien, Phyllis C; Gross, Robert; Brown, Todd T; Abdel-Mohsen, Mohamed.
Afiliação
  • Giron LB; The Wistar Institute, Philadelphia, PA, USA.
  • Liu Q; The Wistar Institute, Philadelphia, PA, USA.
  • Adeniji OS; The Wistar Institute, Philadelphia, PA, USA.
  • Yin X; The Wistar Institute, Philadelphia, PA, USA.
  • Kannan T; The Wistar Institute, Philadelphia, PA, USA.
  • Ding J; The Wistar Institute, Philadelphia, PA, USA.
  • Lu DY; The Wistar Institute, Philadelphia, PA, USA.
  • Langan S; Cornell University, New York, NY, USA.
  • Zhang J; Johns Hopkins University, Baltimore, MD, USA.
  • Azevedo JLLC; Johns Hopkins University, Baltimore, MD, USA.
  • Li SH; The Wistar Institute, Philadelphia, PA, USA.
  • Shalygin S; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Azadi P; University of Georgia, Athens, GA, USA.
  • Hanna DB; University of Georgia, Athens, GA, USA.
  • Ofotokun I; Albert Einstein College of Medicine, Bronx, NY, USA.
  • Lazar J; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
  • Fischl MA; SUNY Downstate Health Sciences University, New York, NY, USA.
  • Haberlen S; Division of Infectious Disease, Department of Medicine, University of Miami, Miami, FL, USA.
  • Macatangay B; Johns Hopkins University, Baltimore, MD, USA.
  • Adimora AA; University of Pittsburgh, Pittsburgh, PA, USA.
  • Jamieson BD; University of North Carolina, Chapel Hill, NC, USA.
  • Rinaldo C; University of California, Los Angeles, Los Angeles, CA, USA.
  • Merenstein D; University of Pittsburgh, Pittsburgh, PA, USA.
  • Roan NR; Georgetown University Medical Center, Washington, DC, USA.
  • Kutsch O; Gladstone Institutes, San Francisco, CA, USA.
  • Gange S; University of California San Francisco, San Francisco, CA, USA.
  • Wolinsky SM; University of Alabama at Birmingham, Birmingham, AL, USA.
  • Witt MD; Johns Hopkins University, Baltimore, MD, USA.
  • Post WS; Northwestern University, Chicago, IL, USA.
  • Kossenkov A; Lundquist Institute of Biomedical Research at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Landay AL; Johns Hopkins University, Baltimore, MD, USA.
  • Frank I; The Wistar Institute, Philadelphia, PA, USA.
  • Tien PC; Rush University, Chicago, IL, USA.
  • Gross R; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Brown TT; University of California San Francisco, San Francisco, CA, USA.
  • Abdel-Mohsen M; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Nat Commun ; 15(1): 3035, 2024 Apr 10.
Article em En | MEDLINE | ID: mdl-38600088
ABSTRACT
People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this vulnerability remain uncertain. In the general population, alterations in the N-glycans on IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG N-glycans in cross-sectional and longitudinal samples from 1214 women and men, living with and without HIV. PLWH exhibit an accelerated accumulation of pro-aging-associated glycan alterations and heightened expression of senescence-associated glycan-degrading enzymes compared to controls. These alterations correlate with elevated markers of inflammation and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit a reduced ability to elicit anti-HIV Fc-mediated immune activities. These findings hold potential for the development of biomarkers and tools to identify and prevent premature aging and comorbidities in PLWH.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Infecções por HIV / Senilidade Prematura Limite: Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Infecções por HIV / Senilidade Prematura Limite: Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos