Neuropathic pain, mood, and stress-related disorders: A literature review of comorbidity and co-pathogenesis.
Neurosci Biobehav Rev
; 161: 105673, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38614452
ABSTRACT
Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10% of the global population. It is becoming increasingly evident that limited or short-lasting response to treatments for neuropathic pain is associated with psychological factors, which include psychiatric comorbidities known to affect quality of life. It is estimated that 60% of patients with neuropathic pain also experience depression, anxiety, and stress symptoms. Altered mood, including stress, can be a consequence of several painful conditions but can also favor pain chronicization when preexisting. Despite the apparent tight connection between clinical pain and mood/stress disorders, the exact physiological mechanisms remain unclear. This review aims to provide an overview of state-of-the-art research on the mechanisms of pain related to the pathophysiology of depression, anxiety, and stress disorders.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Comorbidade
/
Neuralgia
Limite:
Humans
Idioma:
En
Revista:
Neurosci Biobehav Rev
Ano de publicação:
2024
Tipo de documento:
Article