Description of Solvent-Extractable Chemicals in Thermal Receipts and Toxicological Assessment of Bisphenol S and Diphenyl Sulfone.
Bull Environ Contam Toxicol
; 112(4): 63, 2024 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-38615298
ABSTRACT
Research on thermal receipts has previously focused on the toxic effects of dermal exposure from the most publicized developers (e.g., bisphenol A (BPA) and bisphenol S (BPS)), while no studies have reported on the other solvent-extractable compounds therein. Diphenyl sulfone (DPS) is a sensitizer added to thermal receipts, but little is known about DPS concentrations in receipts or potential toxicity. Here, we quantified BPA, BPS, and DPS concentrations and tentatively identified the solvent-extractable compounds of thermal receipts collected from three South Dakota (USA) cities during 2016-2017. An immortalized chicken hepatic cell line, cultured as 3D spheroids, was used to screen effects of DPS, BPS, and 17ß estradiol (E2; 0.1-1000 µM) on cell viability and gene expression changes. These chemicals elicited limited cytotoxicity with LC50 values ranging from 113 to 143 µM, and induced dysregulation in genes associated with lipid and bile acid homeostasis. Taken together, this study generated novel information on solvent-extractable chemicals from thermal receipts and toxicity data for DPS.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fenóis
/
Sulfonas
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Compostos Benzidrílicos
/
Compostos de Bifenilo
Idioma:
En
Revista:
Bull Environ Contam Toxicol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá