A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow.

Lin, Xin-Jie; Wang, Chien-Lung; Peng, Chi-How; Liu, Hsueh-Ju; Wu, Yen-Ku

Lin, Xin-Jie; Wang, Chien-Lung; Peng, Chi-How; Liu, Hsueh-Ju; Wu, Yen-Ku.

Afiliação

Lin XJ; Department of Applied Chemistry, National Yang Ming Chiao Tung University, No. 1001 University Road, Hsinchu, 30010, Taiwan.
Wang CL; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan.
Peng CH; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan.
Liu HJ; Department of Applied Chemistry, National Yang Ming Chiao Tung University, No. 1001 University Road, Hsinchu, 30010, Taiwan.
Wu YK; Department of Applied Chemistry, National Yang Ming Chiao Tung University, No. 1001 University Road, Hsinchu, 30010, Taiwan.

Chem Asian J ; 19(13): e202400269, 2024 Jul 02.

Article em En | MEDLINE | ID: mdl-38619083

ABSTRACT

ABSTRACT

Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.

Palavras-chave

hydroxybenzophenone; oxygen donor ligand; phenol; photo-Fries rearrangement; photoflow synthesis

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Chem Asian J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan