Prmt7 is required for the osteogenic differentiation of mesenchymal stem cells via modulation of BMP signaling.
BMB Rep
; 57(7): 330-335, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38627951
ABSTRACT
Arginine methylation, which is catalyzed by protein arginine methyltransferases (Prmts), is known to play a key role in various biological processes. However, the function of Prmts in osteogenic differentiation of mesenchymal stem cells (MSCs) has not been clearly understood. In the current study, we attempted to elucidate a positive role of Prmt7 in osteogenic differentiation. Prmt7-depleted C3H/10T1/2 cells or bone marrow mesenchymal stem cells (BMSCs) showed the attenuated expression of osteogenic specific genes and Alizarin red staining compared to the wild-type cells. Furthermore, we found that Prmt7 deficiency reduced the activation of bone morphogenetic protein (BMP) signaling cascade, which is essential for the regulation of cell fate commitment and osteogenesis. Taken together, our data indicate that Prmt7 plays important regulatory roles in osteogenic differentiation. [BMB Reports 2024; 57(7) 330-335].
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Osteogênese
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Proteína-Arginina N-Metiltransferases
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Transdução de Sinais
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Diferenciação Celular
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Proteínas Morfogenéticas Ósseas
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Células-Tronco Mesenquimais
Limite:
Animals
Idioma:
En
Revista:
BMB Rep
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2024
Tipo de documento:
Article