Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma.
Genes Chromosomes Cancer
; 63(4): e23239, 2024 04.
Article
em En
| MEDLINE
| ID: mdl-38656544
ABSTRACT
Myxoid leiomyosarcoma (MLS) is a rare but well-documented tumor that often portends a poor prognosis compared to the conventional leiomyosarcoma. This rare sarcoma has been reported in the uterus, external female genitalia, soft tissue, and other locations. However, a definite rectal MLS has not been reported. Recently five cases of MLS were reported to harbor PLAG1 fusions (TRPS1PLAG1, RAD51BPLAG1, and TRIM13PLAG1). In this report, we present a case of rectal MLS with a novel MIR143HGPLAG1 fusion detected by RNA next-generation sequencing.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Proteínas de Ligação a DNA
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Leiomiossarcoma
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Genes Chromosomes Cancer
Assunto da revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos