Brain-muscle communication prevents muscle aging by maintaining daily physiology.
Science
; 384(6695): 563-572, 2024 May 03.
Article
em En
| MEDLINE
| ID: mdl-38696572
ABSTRACT
A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Encéfalo
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Envelhecimento
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Ritmo Circadiano
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Músculo Esquelético
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Senilidade Prematura
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha