Automated radiosynthesis of [11C]CPPC for in-human PET imaging applications.
Am J Nucl Med Mol Imaging
; 14(2): 144-148, 2024.
Article
em En
| MEDLINE
| ID: mdl-38737641
ABSTRACT
The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of microglia availability. [11C]CPPC has specific binding affinity to CSF1R and suitable kinetic properties for in vivo PET imaging of microglia. However, previous studies reported a low radiochemical yield, motivating additional research to optimize [11C]CPPC radiochemistry. In this work, we report an automated radiosynthesis of [11C]CPPC on a Synthra MeIPlus module with improved radiochemical yield. The final [11C]CPPC product was obtained with excellent chemical/radiochemical purities and molecular activity, facilitating high-quality in-human PET imaging applications.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Am J Nucl Med Mol Imaging
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos