Expanding Clinical Spectrum of Anti-GQ1b Antibody Syndrome: A Review.
JAMA Neurol
; 81(7): 762-770, 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38739407
ABSTRACT
Importance The discovery of the anti-GQ1b antibody has expanded the nosology of classic Miller Fisher syndrome to include Bickerstaff brainstem encephalitis, Guillain-Barré syndrome with ophthalmoplegia, and acute ophthalmoplegia without ataxia, which have been brought under the umbrella term anti-GQ1b antibody syndrome. It seems timely to define the phenotypes of anti-GQ1b antibody syndrome for the proper diagnosis of this syndrome with diverse clinical presentations. This review summarizes these syndromes and introduces recently identified subtypes. Observations Although ophthalmoplegia is a hallmark of anti-GQ1b antibody syndrome, recent studies have identified this antibody in patients with acute vestibular syndrome, optic neuropathy with disc swelling, and acute sensory ataxic neuropathy of atypical presentation. Ophthalmoplegia associated with anti-GQ1b antibody positivity is complete in more than half of the patients but may be monocular or comitant. The prognosis is mostly favorable; however, approximately 14% of patients experience relapse. Conclusions and Relevance Anti-GQ1b antibody syndrome may present diverse neurological manifestations, including ophthalmoplegia, ataxia, areflexia, central or peripheral vestibulopathy, and optic neuropathy. Understanding the wide clinical spectrum may aid in the differentiation and management of immune-mediated neuropathies with multiple presentations.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Oftalmoplegia
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Síndrome de Miller Fisher
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Gangliosídeos
Limite:
Humans
Idioma:
En
Revista:
JAMA Neurol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Coréia do Sul