Protective Effects of ß-Blockers on Bone in Older Adults with Dementia.
Calcif Tissue Int
; 115(1): 14-22, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38744723
ABSTRACT
Increased ß-adrenergic receptor activity has been hypothesized to cause bone loss in those with dementia. We investigated the effect of long-term ß-blocker use on rate of bone loss in older adults with dementia. We used a linear mixed-effects model to estimate the relationship between long-term ß-blocker use and rate of bone loss in participants from the Health Aging and Body Composition study. Records of 1198 participants were analyzed, 44.7% were men. Among the men, 25.2% had dementia and 20.2% were on ß-blockers, while in the women, 22.5% had dementia and 16.6% received ß-blockers. In the 135 men with dementia, 23 were taking ß-blockers, while 15 of 149 women with dementia were using ß-blockers. In men with dementia, ß-blocker users had 0.00491 g/cm2 less bone mineral density (BMD) loss per year at the femoral neck (i.e., 0.63% less loss per year) than non-users (p < 0.05). No differences were detected in women with or without dementia and men without dementia. ß-blockers may be protective by slowing down bone loss in older men with dementia.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Densidade Óssea
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Antagonistas Adrenérgicos beta
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Demência
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Calcif Tissue Int
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos