ATPSpin: A Single Microfluidic Platform that Produces Diversified ATPS-Alginate Microfibers.
ACS Biomater Sci Eng
; 10(6): 3896-3908, 2024 06 10.
Article
em En
| MEDLINE
| ID: mdl-38748191
ABSTRACT
Microfluidic spinning is emerging as a useful technique in the fabrication of alginate fibers, enabling applications in drug screening, disease modeling, and disease diagnostics. In this paper, by capitalizing on the benefits of aqueous two-phase systems (ATPS) to produce diverse alginate fiber forms, we introduce an ATPS-Spinning platform (ATPSpin). This ATPS-enabled method efficiently circumvents the rapid clogging challenges inherent to traditional fiber production techniques by regulating the interaction between alginate and cross-linking agents like Ba2+ ions. By varying system parameters under the guidance of a regime map, our system produces several fiber formsâsolid, hollow, and droplet-filledâconsistently and reproducibly from a single device. We demonstrate that the resulting alginate fibers possess distinct features, including biocompatibility. We also encapsulate HEK293 cells in the microfibers as a proof-of-concept that this versatile microfluidic fiber generation platform may have utility in tissue engineering and regenerative medicine applications.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Alginatos
Limite:
Humans
Idioma:
En
Revista:
ACS Biomater Sci Eng
Ano de publicação:
2024
Tipo de documento:
Article