Combined or High Dose Immunosuppression in Inflammatory Bowel Disease patients who are NUDT15 Homozygous Harbors Risk of Developing Invasive Fungal Infections: A Case Series.

Thomas, David Mathew; Mundhra, Sandeep Kumar; Prasad, Shubham; Swaroop, Shekhar; Arora, Umang; Ahmed, Syed; Bhalla, Ashu Seith; Sharma, Raju; Das, Prasenjit; Kedia, Saurabh; Ahuja, Vineet

Thomas, David Mathew; Mundhra, Sandeep Kumar; Prasad, Shubham; Swaroop, Shekhar; Arora, Umang; Ahmed, Syed; Bhalla, Ashu Seith; Sharma, Raju; Das, Prasenjit; Kedia, Saurabh; Ahuja, Vineet.

Afiliação

Thomas DM; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Mundhra SK; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Prasad S; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Swaroop S; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Arora U; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Ahmed S; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Bhalla AS; Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, India.
Sharma R; Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, India.
Das P; Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.
Kedia S; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Ahuja V; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.

Inflamm Bowel Dis ; 30(9): 1623-1625, 2024 Sep 03.

Article em En | MEDLINE | ID: mdl-38757903

NUDT15 homozygous mutations predispose patients to severe leucopenia, which invites risk of disseminated fungal infections when high doses or a combination of immunosuppressives are administered in this patient population.

Assuntos

Imunossupressores; Doenças Inflamatórias Intestinais; Pirofosfatases; Humanos; Doenças Inflamatórias Intestinais/genética; Doenças Inflamatórias Intestinais/tratamento farmacológico; Feminino; Imunossupressores/efeitos adversos; Masculino; Pirofosfatases/genética; Adulto; Infecções Fúngicas Invasivas/genética; Homozigoto; Pessoa de Meia-Idade; Nudix Hidrolases

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pirofosfatases / Doenças Inflamatórias Intestinais / Imunossupressores Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

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