MHC tetramer technology: Exploring T cell biology in health and disease.
Adv Protein Chem Struct Biol
; 140: 327-345, 2024.
Article
em En
| MEDLINE
| ID: mdl-38762273
ABSTRACT
Major histocompatibility complex (MHC) tetramers stand as formidable tools within T cell biology, facilitating the exploration and comprehension of immune responses. These artificial molecules, comprising four bound MHC molecules, typically with a specified peptide and a fluorescent label, play a pivotal role in characterizing T cell subsets, monitoring clonal expansion, and unraveling T cell dynamics during responses to infections or immunotherapies. Beyond their applications in T cell biology, MHC tetramers prove valuable in investigating a spectrum of diseases such as infectious diseases, autoimmune disorders, and cancers. Their instrumental role extends to vaccine research and development. Notably, when appropriately configured, tetramers transcend T cell biology research and find utility in exploring natural killer T cells and contributing to specific T cell clonal deletions.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Complexo Principal de Histocompatibilidade
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Protein Chem Struct Biol
/
Advances in protein chemistry and structural biology (Online)
Assunto da revista:
BIOLOGIA
/
BIOQUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia