Adjunctive Chinese medicine therapy reduces relapse of psoriasis vulgaris after discontinuation of biologics: a prospective registry-based cohort study.
J Dermatolog Treat
; 35(1): 2355261, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-38767401
ABSTRACT
BACKGROUND:
Biologics have revolutionized psoriasis treatment; however, relapse of psoriasis after discontinuation of biologics remains unresolved.OBJECTIVE:
To assess the impact of adjunctive Chinese medicine (CM) therapy on relapse of psoriasis vulgaris (PV) after discontinuation of biologics.METHODS:
We constructed a prospective cohort study through a psoriasis case registry platform that enrolled patients treated with biologics (in combination with or without CM). The endpoint event was relapse, defined as loss of psoriasis area and severity index (PASI) 75.RESULTS:
A total of 391 patients completed the study and were included in the analysis, of whom 169 (43.2%) experienced relapse during follow-up. To minimize the bias, a 11 propensity score matching (PSM) was performed, generating matched cohorts of 156 individuals per group. Adjuvant CM therapy significantly associated with reduced incidence of relapse (HR =0.418, 95% CI = 0.289 â¼ 0.604, p < 0.001), and the protective effect of CM in the subgroup analysis was significant. In addition, PASI 90 response and disease duration were associated with relapse (p < 0.05).CONCLUSION:
Adjunctive CM therapy is associated with reduced relapse incidence in PV after discontinuation of biologics.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Psoríase
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Recidiva
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Produtos Biológicos
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Índice de Gravidade de Doença
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Sistema de Registros
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Dermatolog Treat
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China