Value of soluble fms-like tyrosine kinase 1 for predicting acute pancreatitis severity: a systematic review and meta-analysis.
Rev Assoc Med Bras (1992)
; 70(5): e20231694, 2024.
Article
em En
| MEDLINE
| ID: mdl-38775515
ABSTRACT
OBJECTIVE:
The objective of this study was to explore the relationship between serum soluble fms-like tyrosine kinase 1 and the severity of acute pancreatitis and its diagnostic utility.METHODS:
This study was carried out by searching Chinese and English literature from the establishment of the database to July 9, 2023, systematically, and assessing the quality and heterogeneity of the articles included.RESULTS:
Thirteen studies with a total of 986 patients were included. Patients with severe acute pancreatitis showed higher levels of soluble fms-like tyrosine kinase 1 compared with mild acute pancreatitis [weighted mean difference=76.64 pg/mL, 95% confidence interval (95%CI 50.39-102.89, p<0.001)]. Soluble fms-like tyrosine kinase 1 predicted pooled sensitivity, specificity, and area under the curve were 79%, 74%, and 0.85 for severe acute pancreatitis, with some heterogeneity (I2>50% or p<0.05). In the subgroup analysis, cutoff >150 pg/mL was found to be a heterogeneous factor.CONCLUSION:
Soluble fms-like tyrosine kinase 1 is a reliable tool for identifying acute pancreatitis severity, but only as a screening tool.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Índice de Gravidade de Doença
/
Biomarcadores
Limite:
Humans
Idioma:
En
Revista:
Rev Assoc Med Bras (1992)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China