A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases.
Cell
; 187(12): 2969-2989.e24, 2024 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-38776919
ABSTRACT
The gut fungal community represents an essential element of human health, yet its functional and metabolic potential remains insufficiently elucidated, largely due to the limited availability of reference genomes. To address this gap, we presented the cultivated gut fungi (CGF) catalog, encompassing 760 fungal genomes derived from the feces of healthy individuals. This catalog comprises 206 species spanning 48 families, including 69 species previously unidentified. We explored the functional and metabolic attributes of the CGF species and utilized this catalog to construct a phylogenetic representation of the gut mycobiome by analyzing over 11,000 fecal metagenomes from Chinese and non-Chinese populations. Moreover, we identified significant common disease-related variations in gut mycobiome composition and corroborated the associations between fungal signatures and inflammatory bowel disease (IBD) through animal experimentation. These resources and findings substantially enrich our understanding of the biological diversity and disease relevance of the human gut mycobiome.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Microbioma Gastrointestinal
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Micobioma
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Fungos
Limite:
Adult
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cell
Ano de publicação:
2024
Tipo de documento:
Article