Mitochondria at the crossroads of health and disease.
Cell
; 187(11): 2601-2627, 2024 May 23.
Article
em En
| MEDLINE
| ID: mdl-38788685
ABSTRACT
Mitochondria reside at the crossroads of catabolic and anabolic metabolism-the essence of life. How their structure and function are dynamically tuned in response to tissue-specific needs for energy, growth repair, and renewal is being increasingly understood. Mitochondria respond to intrinsic and extrinsic stresses and can alter cell and organismal function by inducing metabolic signaling within cells and to distal cells and tissues. Here, we review how the centrality of mitochondrial functions manifests in health and a broad spectrum of diseases and aging.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2024
Tipo de documento:
Article