ISR pathway contribution to tissue specificity of mitochondrial diseases.
Trends Endocrinol Metab
; 2024 May 27.
Article
em En
| MEDLINE
| ID: mdl-38806299
ABSTRACT
Mitochondrial genetic defects caused by whole-body mutations typically affect different tissues in different ways. Elucidating the molecular determinants that cause certain cell types to be primarily affected has become a critical research target within the field. We propose a differential activation of the integrated stress response as a potential contributor to this tissue specificity.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
Trends Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha