Lipid-based microemulsion gel for the topical delivery of methotrexate: an optimized, rheologically acceptable formulation with conducive dermatokinetics.
Arch Dermatol Res
; 316(6): 316, 2024 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-38822884
ABSTRACT
In the present study, we have formulated a methotrexate (MTX)-loaded microemulsion topical gel employing quality-by-design optimization. The optimized lipid-based microemulsion was incorporated into a 2% carbopol gel. The prepared formulation was characterized for micromeritics, surface charge, surface morphology, conductivity studies, rheology studies, texture analysis/spreadability, drug entrapment, and drug loading studies. The formulation was further evaluated for drug release and release kinetics, cytotoxicity assays, drug permeation and drug retention studies, and dermatokinetics. The developed nanosystem was not only rheologically acceptable but also offered substantial drug entrapment and loading. From drug release studies, it was observed that the nanogel showed higher drug release at pH 5.0 compared to plain MTX, plain gel, and plain microemulsion. The developed system with improved dermatokinetics, nanometric size, higher drug loading, and enhanced efficacy towards A314 squamous epithelial cells offers a huge promise in the topical delivery of methotrexate.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Absorção Cutânea
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Metotrexato
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Emulsões
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Liberação Controlada de Fármacos
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Géis
Limite:
Animals
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Humans
Idioma:
En
Revista:
Arch Dermatol Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia