Catching the Culprit: Benzylpenicillin Neurotoxicity Confirmed by Therapeutic Drug Monitoring in a Critically Ill Patient With Continuous Venovenous Hemofiltration.
Ther Drug Monit
; 46(4): 556-558, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38840334
ABSTRACT
ABSTRACT We present the case of a 65-year-old patient who was treated with high-dose benzylpenicillin for severe invasive pneumococcal pneumonia, complicated by acute renal failure managed with continuous venovenous hemofiltration. After cessation of continuous venovenous hemofiltration, the patient experienced multiple tonic-clonic seizures. Therapeutic drug monitoring revealed high total serum concentrations of benzylpenicillin, identifying it as the likely cause of the neurotoxicity. This case study presents the first documented total serum benzylpenicillin concentration associated with neurotoxicity.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Penicilina G
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Monitoramento de Medicamentos
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Estado Terminal
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Síndromes Neurotóxicas
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Antibacterianos
Limite:
Aged
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Humans
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Male
Idioma:
En
Revista:
Ther Drug Monit
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Holanda