Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study.
J Perinatol
; 2024 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-38844521
ABSTRACT
OBJECTIVE:
To explore the association between antenatal magnesium sulfate (MgSO4), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants. STUDYDESIGN:
Retrospective, cohort study of infants <32 weeks' GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities.RESULTS:
7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49-0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50-0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72-1.71]). No differences between groups were observed in rates of morbidities.CONCLUSION:
Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
J Perinatol
/
J. perinatol
/
Journal of perinatology
Assunto da revista:
PERINATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Uruguai