Your browser doesn't support javascript.
loading
Rational Design of Activatable Lanthanide NIR-IIb Emissive Nanoprobe for In Situ Specific Imaging of HOCl In Vivo.
Bi, Shenghui; Wen, Xingwang; Wu, Zezheng; Wang, Chunxia; Huang, Hao; Liu, Zhiqiu; Zeng, Songjun.
Afiliação
  • Bi S; School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisc
  • Wen X; School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisc
  • Wu Z; School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisc
  • Wang C; School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisc
  • Huang H; School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisc
  • Liu Z; School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisc
  • Zeng S; School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisc
Small ; 20(42): e2400883, 2024 Oct.
Article em En | MEDLINE | ID: mdl-38881331
ABSTRACT
Hypochlorous acid (HOCl), as an indispensable signaling molecule in organisms, is one of the key members of reactive oxygen species (ROS). However, in vivo, real-time dynamic near-infrared fluorescence imaging of HOCl levels in the 1400-1700 nm sub-window (NIR-IIb) remains a major challenge due to the lack of suitable detection methods. Herein, a general design of HOCl-responsive NIR-IIb fluorescence nanoprobe is proposed by integrating NaLuF4Yb/Er@NaLuF4 downshift nanoparticles (DSNPs) and HOCl recognition/NIR-IIb emissive modulation unit of M2-xS (M = Cu, Co, Pb) nanodots for real-time monitoring of HOCl levels. The fluorescence modulation unit of M2-xS nanodots presents remarkably enhanced absorption than Yb sensitizer at 980 nm and greatly inhibits the NIR-IIb fluorescence emission via competitive absorption mechanism. While, the M2-xS nanodots are easily degraded after triggering by HOCl, resulting in HOCl responsive turn-on (≈ten folds) NIR-IIb emission at 1532 nm. More importantly, in vivo highly precise and specific monitoring of inflammatory with abnormal HOCl expression is successfully achieved. Thus, the explored competitive absorption mediated quenching-activation mechanism provides a new general strategy of designing HOCl-responsive NIR-IIb fluorescence nanoprobe for highly specific and sensitive HOCl detection.
Assuntos
Palavras-chave

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ácido Hipocloroso / Elementos da Série dos Lantanídeos Limite: Animals Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ácido Hipocloroso / Elementos da Série dos Lantanídeos Limite: Animals Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article