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Radical Prostatectomy Without Prior Biopsy in Selected Patients Evaluated by 18F-Labeled Prostate-Specific Membrane Antigen-Ligand Positron Emission Tomography/Computed Tomography and Multiparameter Magnetic Resonance Imaging: A Single-Center, Prospective, Single-Arm Trial.
Niu, Shaoxi; Ding, Xiaohui; Liu, Baichuan; Ao, Liyan; Wang, Haiyi; Chen, Wei; Xu, Baixuan; Olivero, Alberto; Liu, Jiajin; Gao, Jiangping; Gao, Yu; Fu, Weijun; Ma, Xin; Li, Hongzhao; Wang, Baojun; Liu, Yachao; Zhang, Xu.
Afiliação
  • Niu S; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
  • Ding X; Department of Pathology, the First Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Liu B; Department of Radiology, the First Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Ao L; Chinese PLA Medical School, Beijing, China.
  • Wang H; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
  • Chen W; Chinese PLA Medical School, Beijing, China.
  • Xu B; Department of Radiology, the First Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Olivero A; Department of Pathology, the First Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Liu J; Department of Nuclear Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Gao J; Department of Urology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Gao Y; Department of Nuclear Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Fu W; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
  • Ma X; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
  • Li H; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
  • Wang B; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
  • Liu Y; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
  • Zhang X; Department of Urology, the Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.
J Urol ; 212(2): 280-289, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38885328
ABSTRACT

PURPOSE:

This study aimed to verify the feasibility and short-term prognosis of prostatectomy without biopsy. MATERIALS AND

METHODS:

Patients with a rising PSA level ranging from 4 to 30 ng/mL were scheduled for multiparametric (mp) MRI and 18F-labeled prostate-specific membrane antigen (PSMA) positron emission tomography (PET). Forty-seven patients (cT2N0M0) with Prostate Imaging Reporting and Data System ≥ 4 and molecular imaging PSMA score ≥ 2 were enrolled. All candidates underwent robot-assisted laparoscopic radical prostatectomy without biopsy. Prostate cancer detection rate, index tumors localization correspondence rate, positive surgical margin, complications, postoperative hospital stay, and PSA level in a 6-week postoperative follow-up visit were collected.

RESULTS:

All the patients with positive mpMRI and PSMA PET were diagnosed with clinically significant prostate cancer. A total of 80 lesions were verified as cancer by pathology, of which 63 cancer lesions were clinically significant prostate cancer. Fifty-one lesions were simultaneously found by mpMRI and PSMA PET. A total of 23 lesions were invisible on either image, and all lesions were ≤ International Society of Urological Pathology 2 or ≤ 15 mm. Forty-five (95.7%) index tumors found by mpMRI combined with PSMA PET were consistent with pathology. Nine patients reported positive surgical margin.

CONCLUSIONS:

Biopsy-free prostatectomy is safe and feasible for patients with evaluation strictly by mpMRI combined with 18F-PSMA PET/CT.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Prostatectomia / Neoplasias da Próstata / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Imageamento por Ressonância Magnética Multiparamétrica Limite: Aged / Humans / Male / Middle aged Idioma: En Revista: J Urol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Prostatectomia / Neoplasias da Próstata / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Imageamento por Ressonância Magnética Multiparamétrica Limite: Aged / Humans / Male / Middle aged Idioma: En Revista: J Urol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China