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Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease-A Comprehensive Review.
Gorini, Francesca; Tonacci, Alessandro.
Afiliação
  • Gorini F; Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
  • Tonacci A; Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Nutrients ; 16(11)2024 Jun 04.
Article em En | MEDLINE | ID: mdl-38892695
ABSTRACT
Autoimmune thyroid diseases (AITD) are among the most frequent autoimmune disorders, with a multifactorial etiology in which both genetic and environmental determinants are probably involved. Celiac disease (CeD) also represents a public concern, given its increasing prevalence due to the recent improvement of screening programs, leading to the detection of silent subtypes. The two conditions may be closely associated due to common risk factors, including genetic setting, changes in the composition and diversity of the gut microbiota, and deficiency of nutrients like vitamin D. This comprehensive review discussed the current evidence on the pivotal role of vitamin D in modulating both gut microbiota dysbiosis and immune system dysfunction, shedding light on the possible relevance of an adequate intake of this nutrient in the primary prevention of AITD and CeD. While future technology-based strategies for proper vitamin D supplementation could be attractive in the context of personalized medicine, several issues remain to be defined, including standardized assays for vitamin D determination, timely recommendations on vitamin D intake for immune system functioning, and longitudinal studies and randomized controlled trials to definitely establish a causal relationship between serum vitamin D levels and the onset of AITD and CeD.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Vitamina D / Deficiência de Vitamina D / Doença Celíaca / Microbioma Gastrointestinal Limite: Humans Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Vitamina D / Deficiência de Vitamina D / Doença Celíaca / Microbioma Gastrointestinal Limite: Humans Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália