The effect of a selenium-based anti-inflammatory strategy on postoperative functional recovery in high-risk cardiac surgery patients - A nested sub-study of the sustain CSX trial.
Life Sci
; 351: 122841, 2024 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-38897349
ABSTRACT
AIM:
The cardiac surgery-related ischemia-reperfusion-related oxidative stress triggers the release of cytotoxic reactive oxygen and nitrogen species, contributing to organ failure and ultimately influencing patients' short- and long-term outcomes. Selenium is an essential co-factor for various antioxidant enzymes, thereby contributing to the patients' endogenous antioxidant and anti-inflammatory defense mechanisms. Given these selenium's pleiotropic functions, we investigated the effect of a high-dose selenium-based anti-inflammatory perioperative strategy on functional recovery after cardiac surgery. MATERIALS ANDMETHODS:
This prospective study constituted a nested sub-study of the SUSTAIN CSX trial, a double-blinded, randomized, placebo-controlled multicenter trial to investigate the impact of high-dose selenium supplementation on high-risk cardiac surgery patients' postoperative recovery. Functional recovery was assessed by 6-min walk distance, Short Form-36 (SF-36) and Barthel Index questionnaires. KEYFINDINGS:
174 patients were included in this sub-study. The mean age (SD) was 67.3 (8.9) years, and 78.7 % of the patients were male. The mean (SD) predicted 30-day mortality by the European System for Cardiac Operative Risk Evaluation II score was 12.6 % (9.4 %). There was no difference at hospital discharge and after three months in the 6-min walk distance between the selenium and placebo groups (131 m [IQR not performed - 269] vs. 160 m [IQR not performed - 252], p = 0.80 and 400 m [IQR 299-461] vs. 375 m [IQR 65-441], p = 0.48). The SF-36 and Barthel Index assessments also revealed no clinically meaningful differences between the selenium and placebo groups.SIGNIFICANCE:
A perioperative anti-inflammatory strategy with high-dose selenium supplementation did not improve functional recovery in high-risk cardiac surgery patients.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Selênio
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Procedimentos Cirúrgicos Cardíacos
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Anti-Inflamatórios
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2024
Tipo de documento:
Article