Systematic review of self-assembling peptides as topical agents for treatment and prevention of gastrointestinal bleeding.
Clin Endosc
; 57(4): 454-465, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38919060
ABSTRACT
BACKGROUND/AIMS:
Gastrointestinal bleeding is a significant and potentially lethal event. We aimed to review the efficiency and safety of self-assembling peptides for the treatment and prevention of gastrointestinal tract bleeding.METHODS:
We conducted a systematic search for studies describing the endoscopic use of self-assembling peptides for treatment or prevention of bleeding in the gastrointestinal tract in a parallel, independent fashion. The primary outcomes were rates of successful initial hemostasis, delayed bleeding, and rebleeding. The secondary outcomes were adverse events and ease and volume of gel used.RESULTS:
Seventeen studies were analyzed. Overall success rate of self-assembling peptides in gastrointestinal bleeding was 87.7% (38%-100%), regardless of etiology or associated treatments. Rebleeding rate ranged from 0% to 16.2%, with a mean of 4.7%, and overall delayed bleeding rate was 5% (range, 0%-15.9%). Only three adverse events were reported in a pooled number of 815 patients. The volume of gel used varied (0.43 to 3.7 mL) according to indication and type of bleeding.CONCLUSIONS:
The limited available data on the use of self-assembling peptides in gastrointestinal endoscopy suggest a high efficiency and good safety profile.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Clin Endosc
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Romênia