Associations of short-term changes in obesity indices with all-cause mortality and cardiovascular disease.
Obesity (Silver Spring)
; 32(8): 1568-1584, 2024 08.
Article
em En
| MEDLINE
| ID: mdl-38924337
ABSTRACT
OBJECTIVE:
This study aimed to investigate how short-term changes (1-, 3-, and 5-year) in obesity measures affect mortality and cardiovascular disease (CVD) risk.METHODS:
We analyzed longitudinal data from the MJ Health Centre (n = 43,304 for the 1-year study; 24,295 for the 3-year study; 16,138 for the 5-year study) with median follow-up periods of 15.8, 13.9, and 12.3 years, respectively. Associations of short-term obesity indices changes with mortality and Framingham Risk Score changes were explored using time-dependent coefficient Cox regression models, restricted cubic splines, and multivariable linear regression models.RESULTS:
All-cause mortality was negatively associated with short-term weight and BMI changes, with greater reductions causing poorer outcomes. Compared with stable groups, short-term reduced weight and BMI were associated with greater risks of all-cause mortality and CVD-specific mortality (5-year study only). Also, either 1- and 3-year reduced or 3-year increased waist circumference and waist to height ratio were related to higher all-cause and CVD deaths than stable groups, respectively. Nonlinear relationships indicated lower cutoff values for short-term changes in obesity indices in predicting all-cause mortality. Decreased obesity indices significantly improved CVD profiles.CONCLUSIONS:
Short-term changes in obesity indices show complex mortality risks, urging personalized approaches beyond a simple weight loss focus.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Índice de Massa Corporal
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Circunferência da Cintura
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Obesidade
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Obesity (Silver Spring)
Assunto da revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China