Boosting endogenous dopamine production: a novel therapeutic approach for Parkinson's disease.

Douma, Erik H; Smidt, Marten P; van der Heide, Lars P

Douma, Erik H; Smidt, Marten P; van der Heide, Lars P.

Afiliação

Douma EH; Parkinnova Therapeutics, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
Smidt MP; Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
van der Heide LP; Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands. Electronic address: l.p.vanderheide@uva.nl.

Trends Mol Med ; 30(9): 800-803, 2024 Sep.

Article em En | MEDLINE | ID: mdl-38926032

ABSTRACT

ABSTRACT

Innovative therapeutic strategies are urgently needed for Parkinson's disease due to limited efficacy of current treatments and a weak therapeutic pipeline. In this forum article, we propose targeting tyrosine hydroxylase phosphorylation as a novel mechanism of action to address this critical need.

Assuntos

Dopamina; Doença de Parkinson; Tirosina 3-Mono-Oxigenase; Doença de Parkinson/metabolismo; Doença de Parkinson/tratamento farmacológico; Humanos; Dopamina/metabolismo; Tirosina 3-Mono-Oxigenase/metabolismo; Tirosina 3-Mono-Oxigenase/genética; Animais; Fosforilação

Palavras-chave

Parkinson's disease; Ser40 phosphorylation; dopamine; levodopa; phosphodiesterase; tyrosine hydroxylase

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doença de Parkinson / Tirosina 3-Mono-Oxigenase / Dopamina Limite: Animals / Humans Idioma: En Revista: Trends Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda

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