The development status of PET radiotracers for evaluating neuroinflammation.
Nucl Med Mol Imaging
; 58(4): 160-176, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38932754
ABSTRACT
Neuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determination of proper treatment of brain diseases. To quantify neuroinflammatory responses in vivo, many PET tracers have been developed using translocator proteins, imidazole-2 binding site, cyclooxygenase, monoamine oxidase-B, adenosine, cannabinoid, purinergic P2X7, and CSF-1 receptors as biomarkers. In this review, we introduce the latest developments in PET tracers that can image neuroinflammation, focusing on clinical trials, and further consider their current implications.
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MEDLINE
Idioma:
En
Revista:
Nucl Med Mol Imaging
Ano de publicação:
2024
Tipo de documento:
Article