Long-term effects of benzodiazepine discontinuation among older adults: potential improvements on depressive symptoms.
Aging Ment Health
; : 1-9, 2024 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-38952209
ABSTRACT
OBJECTIVES:
To examine how change in benzodiazepine (BZD) use is linked to changes in depressive symptoms intensity, worry intensity, and sleep quality over 16 months.METHOD:
Data come from a larger randomised controlled trial (RCT) named the 'Programme d'Aide du Succès au SEvrage (PASSE-60+)' study (NCT02281175). Seventy-three participants age 60 years and older took part in a 4-month discontinuation programme and were assessed four times over 16 months. Change in BZD use was defined as the difference in reported mg/day between two assessments. Control variables were RCT discontinuation group; BZD use at T1; and either depressive symptoms, worry intensity, or sleep quality at T1. Hierarchical multiple regressions were used to analyse data.RESULTS:
In the short term, right after the discontinuation programme, sleep quality worsened with lower BZD use. This link was no longer significant at the 3- and 12-month follow-up. In the long term, depressive symptoms lowered with lower BZD use. No change was found in worry intensity in relation to BZD use at all measurement times.CONCLUSION:
Discontinuation may improve depressive symptoms. Our study also questions the long-term effectiveness of BZD use, since long-term discontinuation was not linked with change in worry intensity and sleep quality.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
Aging & mental health
/
Aging Ment Health
/
Aging ment. health
Assunto da revista:
GERIATRIA
/
PSICOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá