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Sex hormone-binding globulin may explain sex differences for glucose homeostasis and incidence of type 2 diabetes: the KORA study.
Raeisi-Dehkordi, Hamidreza; Amiri, Mojgan; Rathmann, Wolfgang; Zeller, Tanja; Adamski, Jerzy; Bano, Arjola; van der Schouw, Yvonne T; Thorand, Barbara; Muka, Taulant; Nano, Jana.
Afiliação
  • Raeisi-Dehkordi H; Department of Global Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center (UMC) Utrecht, Utrecht University, Utrecht, The Netherlands. H.Raeisidehkordi@umcutrecht.nl.
  • Amiri M; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. H.Raeisidehkordi@umcutrecht.nl.
  • Rathmann W; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Zeller T; Institute for Biometry and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
  • Adamski J; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
  • Bano A; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany.
  • van der Schouw YT; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
  • Thorand B; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore.
  • Muka T; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, 1000, Slovenia.
  • Nano J; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Eur J Epidemiol ; 39(8): 915-924, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38954350
ABSTRACT
Research has indicated that sex hormone-binding globulin (SHBG) is associated with glucose homeostasis and may play a role in the etiology of type 2 diabetes (T2D). While it is unclear whether SHBG may mediate sex differences in glucose control and subsequently, incidence of T2D. We used observational data from the German population-based KORA F4 study (n = 1937, mean age 54 years, 41% women) and its follow-up examination KORA FF4 (median follow-up 6.5 years, n = 1387). T2D was initially assessed by self-report and validated by contacting the physicians and/ or reviewing the medical charts. Mediation analyses were performed to assess the role of SHBG in mediating the association between sex (women vs. men) and glucose- and insulin-related traits (cross-sectional analysis) and incidence of T2D (longitudinal analysis). After adjustment for confounders, (model 1 adjusted for age; model 2 model 1 + smoking + alcohol consumption + physical activity), women had lower fasting glucose levels compared to men (ß = -4.94 (mg/dl), 95% CI -5.77, -4.11). SHBG levels were significantly higher in women than in men (ß = 0.47 (nmol/l), 95% CI0.42, 0.51). Serum SHBG may mediate the association between sex and fasting glucose levels with a proportion mediated (PM) of 30% (CI 22-41%). Also, a potential mediatory role of SHBG was observed for sex differences in incidence of T2D (PM = 95% and 63% in models 1 and 2, respectively). Our novel findings suggest that SHBG may partially explain sex-differences in glucose control and T2D incidence.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Glicemia / Globulina de Ligação a Hormônio Sexual / Diabetes Mellitus Tipo 2 / Homeostase Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Eur J Epidemiol Assunto da revista: EPIDEMIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Glicemia / Globulina de Ligação a Hormônio Sexual / Diabetes Mellitus Tipo 2 / Homeostase Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Eur J Epidemiol Assunto da revista: EPIDEMIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda