Low-dose ionizing radiation generates a hormetic response to modify lipid metabolism in Chlorella sorokiniana.
Commun Biol
; 7(1): 821, 2024 Jul 06.
Article
em En
| MEDLINE
| ID: mdl-38969726
ABSTRACT
Algal biomass is a viable source of chemicals and metabolites for various energy, nutritional, medicinal and agricultural uses. While stresses have commonly been used to induce metabolite accumulation in microalgae in attempts to enhance high-value product yields, this is often very detrimental to growth. Therefore, understanding how to modify metabolism without deleterious consequences is highly beneficial. We demonstrate that low-doses (1-5 Gy) of ionizing radiation in the X-ray range induces a non-toxic, hormetic response in microalgae to promote metabolic activation. We identify specific radiation exposure parameters that give reproducible metabolic responses in Chlorella sorokiniana caused by transcriptional changes. This includes up-regulation of >30 lipid metabolism genes, such as genes encoding an acetyl-CoA carboxylase subunit, phosphatidic acid phosphatase, lysophosphatidic acid acyltransferase, and diacylglycerol acyltransferase. The outcome is an increased lipid yield in stationary phase cultures by 25% in just 24 hours, without any negative effects on cell viability or biomass.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Chlorella
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Metabolismo dos Lipídeos
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Hormese
Idioma:
En
Revista:
Commun Biol
Ano de publicação:
2024
Tipo de documento:
Article