Palladium-Catalyzed para-Selective C-H Olefination and Acetoxylation of Benzylamines Enabled by an Unmasked Benzoyl Template.
Org Lett
; 26(29): 6109-6113, 2024 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-39023060
ABSTRACT
Benzylamines belong to an important class of building blocks in the synthesis of biologically active natural products and drugs. Encumbered by amide-directed ortho-C-H activation, remote para-selective C-H functionalization of benzylamines has hitherto not been realized to date. Here, we report a palladium-catalyzed para-selective C-H olefination and acetoxylation of benzylamines using a functionalized benzoyl template. Enhancing the coordination strength of the directing group in the template significantly improved the site selectivity of C-H functionalization.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2024
Tipo de documento:
Article