Insulin and the blood-brain barrier.
Vitam Horm
; 126: 169-190, 2024.
Article
em En
| MEDLINE
| ID: mdl-39029972
ABSTRACT
The blood-brain barrier (BBB) predominantly regulates insulin transport into and levels within the brain. The BBB is also an important site of insulin binding and mediator of insulin receptor (INSR) signaling. The insulin transporter is separate from the INSR, highlighting the important, unique role of each protein in this structure. After a brief introduction on the structure of insulin and the INSR, we discuss the importance of insulin interactions at the BBB, the properties of the insulin transporter and the role of the BBB insulin transporter in various physiological conditions. We go on to further describe insulin BBB signaling and the impact not only within brain endothelial cells but also the cascade into other cell types within the brain. We close with future considerations to advance our knowledge about the importance of insulin at the BBB.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Receptor de Insulina
/
Barreira Hematoencefálica
/
Insulina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Vitam Horm
Ano de publicação:
2024
Tipo de documento:
Article