Isotretinoin-Induced Hypersomnia: A Cross-sectional Study and Literature Review.
Adv Skin Wound Care
; 37(8): 1-3, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39037104
ABSTRACT
BACKGROUND:
Isotretinoin is an oral retinoic drug for severe resistant acne cases that has controversially been associated with multiple psychiatric adverse effects. Research has primarily focused on depression and suicidality; however, a few case studies reported hypersomnia and sleep changes after isotretinoin initiation.OBJECTIVE:
To assess sleep quality and measure rates of hypersomnia, depression, and anxiety in patients undergoing isotretinoin therapy.METHODS:
This cross-sectional study was conducted at outpatient clinics of the university hospital. The rate of self-reported oversleeping was measured. In addition, researchers used the Pittsburgh Sleep Quality Index to assess sleep quality and conducted semistructured clinical interviews to detect depression and anxiety.RESULTS:
Of 123 patients with acne on isotretinoin, 77 (62.6%) reported oversleeping. Nearly half (60 patients, 48.8%) were categorized as poor sleepers according to the Pittsburgh Sleep Quality Index. The interviews revealed anxiety and depression percentages among 9.8% and 4.9% of participants, respectively.CONCLUSIONS:
Hypersomnia was noticeably high in this study sample; thus, it may cautiously suggest a possible link between isotretinoin and hypersomnia. However, more research is needed to investigate this potential relationship.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Isotretinoína
/
Acne Vulgar
/
Fármacos Dermatológicos
/
Distúrbios do Sono por Sonolência Excessiva
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Adv Skin Wound Care
Assunto da revista:
ENFERMAGEM
Ano de publicação:
2024
Tipo de documento:
Article