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High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains.
Schwabenland, Marius; Hasavci, Dilara; Frase, Sibylle; Wolf, Katharina; Deigendesch, Nikolaus; Buescher, Joerg M; Mertz, Kirsten D; Ondruschka, Benjamin; Altmeppen, Hermann; Matschke, Jakob; Glatzel, Markus; Frank, Stephan; Thimme, Robert; Beck, Juergen; Hosp, Jonas A; Blank, Thomas; Bengsch, Bertram; Prinz, Marco.
Afiliação
  • Schwabenland M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.
  • Hasavci D; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.
  • Frase S; Department of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Wolf K; Department of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Deigendesch N; Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany.
  • Buescher JM; Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Mertz KD; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.
  • Ondruschka B; Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.
  • Altmeppen H; University of Basel, Basel, Switzerland.
  • Matschke J; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Frank S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Thimme R; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Beck J; Division of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Hosp JA; Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.
  • Blank T; Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany.
  • Bengsch B; Department of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.
Acta Neuropathol ; 148(1): 11, 2024 Jul 25.
Article em En | MEDLINE | ID: mdl-39060438
ABSTRACT
The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119+P2RY12+CD68+Iba1+HLA-DR+CD11c+SCAMP2+ microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8+ parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Encéfalo / COVID-19 / Imunidade Inata Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Encéfalo / COVID-19 / Imunidade Inata Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha