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The role of FDG PET/CT radiomics in the prediction of pathological response to neoadjuvant treatment in patients with esophageal cancer.
Eifer, Michal; Peters-Founshtein, Gregory; Yoel, Lotem Cohn; Pinian, Hodaya; Steiner, Roee; Klang, Eyal; Catalano, Onofrio A; Eshet, Yael; Domachevsky, Liran.
Afiliação
  • Eifer M; Department of Nuclear Imaging, Sheba Medical Center, Ramat Gan, Israel.
  • Peters-Founshtein G; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Yoel LC; Department of Nuclear Imaging, Sheba Medical Center, Ramat Gan, Israel.
  • Pinian H; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Steiner R; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Klang E; Department of Nuclear Imaging, Sheba Medical Center, Ramat Gan, Israel.
  • Catalano OA; Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.
  • Eshet Y; Sharee Zedek Medical Center, Jerusalem, Israel.
  • Domachevsky L; Department of Nuclear Imaging, Sheba Medical Center, Ramat Gan, Israel.
Rep Pract Oncol Radiother ; 29(2): 211-218, 2024.
Article em En | MEDLINE | ID: mdl-39143975
ABSTRACT

Background:

Attainment of a complete histopathological response following neoadjuvant therapy has been associated with favorable long-term survival outcomes in esophageal cancer patients. We investigated the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) radiomic features to predict the pathological response to neoadjuvant treatment in patients with esophageal cancer. Materials and

methods:

A retrospective review of medical records of patients with locally advanced resectable esophageal or esophagogastric junctional cancers. Included patients had a baseline FDG PET/CT scan and underwent Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) protocol followed by surgery. Four demographic variables and 107 PET radiomic features were extracted and analyzed using univariate and multivariate analyses to predict response to neoadjuvant therapy.

Results:

Overall, 53 FDG-avid primary esophageal cancer lesions were segmented and radiomic features were extracted. Seventeen radiomic features and 2 non-radiomics variables were found to exhibit significant differences between neoadjuvant therapy responders and non-responders. An unsupervised hierarchical clustering analysis using these 19 variables classified patients in a manner significantly associated with response to neoadjuvant treatment (p < 0.01).

Conclusion:

Our findings highlight the potential of FDG PET/CT radiomic features as a predictor for the response to neoadjuvant therapy in esophageal cancer patients. The combination of these radiomic features with select non-radiomic variables provides a model for stratifying patients based on their likelihood to respond to neoadjuvant treatment.
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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Rep Pract Oncol Radiother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Israel

Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Rep Pract Oncol Radiother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Israel