Approach to Mycosis Fungoides in children (ARMFUL study): consensus-based recommendations.
J Am Acad Dermatol
; 2024 Aug 22.
Article
em En
| MEDLINE
| ID: mdl-39181404
ABSTRACT
BACKGROUND:
Pediatric Mycosis Fungoides (MF) management extrapolates from adult guidelines, despite differing clinical aspects. Recommendations are essential to address unique challenges in this distinct patient group.OBJECTIVE:
This project aims to derive consensus recommendations for pediatric MF management.METHODS:
Experts from pediatric dermatology, general dermatology, dermato-pathology, and pediatric hematology-oncology (N=83) were invited to contribute to consensus recommendations. The process involved three eDelphi rounds, concluding with a final consensus meeting using a modified Nominal Group Technique for unresolved items.RESULTS:
Consensus included more clinical severity measures than TNMB staging pruritus, functional or esthetic impairment (e.g., palms, soles, genitalia), quality of life impact, and psychological aspects (e.g., embarrassment, anxiety, depression), plus parental anxiety. Ten recommendations were made for managing early and advanced pediatric MF. Disagreement emerged in choosing therapies beyond stage I of the disease.DISCUSSION:
This multinational initiative aimed to standardize optimal pediatric MF management and successfully generated consensus recommendations. Additional work is needed for structured, prospective protocols in advanced-stage pediatric MF.LIMITATIONS:
Lack of pediatric hematologists-oncologists and patients' representatives.CONCLUSION:
Documentation of extended clinical severity and outcome measures is recommended. Addressing the need for structured protocols in advanced-stage pediatric MF and implementing systematic, prospective data collection is crucial..
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2024
Tipo de documento:
Article