Development of a cationic bacterial cellulose film loaded with anionic liposomes for prolonged release of oxacillin in wound dressing applications.
Int J Pharm
; 665: 124649, 2024 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-39236774
ABSTRACT
Dressings should protect wounds, promote healing, absorb fluids, and maintain moisture. Bacterial cellulose is a biopolymer that stands out in biomaterials due to its high biocompatibility in several applications. In the area of dressings, it is already marketed as an alternative to traditional dressings. However, it lacks any intrinsic activity; among these, the need for antimicrobial activity in infected wounds stands out. We developed a cationic cellulose film by modifying cellulose with 1-(5-carboxypentyl)pyridin-1-ium bromide, enhancing its wettability (contact angle 26.6°) and water retention capacity (2714.37 %). This modified film effectively retained oxacillin compared to the unmodified control. Liposomal encapsulation further prolonged oxacillin release up to 11 days. Both oxacillin-loaded films and liposomal formulations demonstrated antimicrobial activity against Staphylococcus aureus. Our findings demonstrate the potential of chemically modified cellulose as a platform for controlled anionic antibiotics and/or their formulations delivery in wound care.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Oxacilina
/
Staphylococcus aureus
/
Bandagens
/
Celulose
/
Preparações de Ação Retardada
/
Liberação Controlada de Fármacos
/
Lipossomos
/
Antibacterianos
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil