[Synthesis and antiinflammatory activity of various 1,4-benzothiazine derivatives]. / Sintesi ed attività antiinfiammatoria di alcuni derivati 1,4-benzotiazinici.
Farmaco Sci
; 40(5): 369-76, 1985 May.
Article
em It
| MEDLINE
| ID: mdl-4007156
ABSTRACT
A new series of dihydro-4H-1,4-benzothiazine derivatives was prepared. These compounds were obtained by reductive N-alkylation reaction with sodium borohydride in acetic acid of the corresponding 4H-1,4-benzothiazine. Some of the latter compounds were synthesized by a new synthetic method employing 2-aminobenzenethiol and alkynes as starting material. Preliminary pharmacological data on the antiinflammatory activity of these compounds by using carrageenin paw edema assay are reported.
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Bases de dados:
MEDLINE
Assunto principal:
Tiazinas
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
It
Revista:
Farmaco Sci
Ano de publicação:
1985
Tipo de documento:
Article