Effect of interferon-alpha 1 from E. coli on some cell functions.
Science
; 209(4463): 1431-5, 1980 Sep 19.
Article
em En
| MEDLINE
| ID: mdl-6158096
ABSTRACT
Interferon-alpha 1 from Escherichia coli transformed with a hybrid plasmid containing a human leukocyte complementary DNA insert, induces resistance to virus in appropriate target cells. It also shares the following properties with natural leukocyte interferon (IFN). (i) It enhances natural killing activity of human lymphocytes, (ii) it enhances antibody-dependent cell-mediated cytotoxicity, (iii) it suppresses antigen- and mitogen-induced leukocyte migration inhibition, (iv) it inhibits growth of IFN-sensitive Burkitt lymphoma cells. Since these activities are exhibited by a cloned protein species, they are due to IFN itself and not to other human proteins.
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Bases de dados:
MEDLINE
Assunto principal:
DNA Recombinante
/
Interferons
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1980
Tipo de documento:
Article