Aucubin: potential antidote for alpha-amanitin poisoning.
J Toxicol Clin Toxicol
; 22(1): 77-85, 1984 Jul.
Article
em En
| MEDLINE
| ID: mdl-6208374
ABSTRACT
Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.
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Bases de dados:
MEDLINE
Assunto principal:
Iridoides
/
Amanitinas
/
Glucosídeos
/
Glicosídeos
/
Antídotos
Limite:
Animals
Idioma:
En
Revista:
J Toxicol Clin Toxicol
Ano de publicação:
1984
Tipo de documento:
Article